1.1 fermentation process the cause of the bubble
1, mixing a strong degree of ventilation
Ventilation, stirring strong bubble will increase, so early in the fermentation due to less consumption of medium nutrients, rich media components and easy foaming. Should be a small ventilation, and then gradually increase. Speed also stirred so. Materials may also join the basis of defoamers.
2, the ratio of medium and material composition
Medium nutrient-rich, viscosity, and lasting more than a bubble, a difficult pre-mixing.
3, bacteria, the quality of seeds and inoculation
Strains of good quality and faster growth, soluble nitrogen faster to be used, the bubble will have little chance. The slow growth of bacteria can increase the amount of inoculation
4, the quality of sterilization
Sterilization medium poor quality, sugar nitrogen was destroyed and inhibit microbial growth, the seeds of mycelium autolysis, a large bubble, and defoamers also invalid.

1.2 foaming hazards
1, reducing production capacity
In the fermentation tank, in order to accommodate the bubble to prevent overflow and reduce the volume of equipment
2, caused a waste of raw materials
If the device can not have a capacity to accommodate room for the bubble, the bubble will cause the loss of raw materials, resulting in waste.
3, the effects of breathing
If the bubble stability, not broken, then the microorganisms with breathing, full of carbon dioxide in the bubbles, but can not with the exchange of oxygen in the air, thus affecting the respiratory bacteria.
4, caused Ranjun
As the bubble increase in the number of defectors from liquid, so the exhaust pipe of Nianshang medium, president of bacteria. With the extension of the time, the president of bacteria into the fermentation tank caused Ranjun. Foam from the tank top a lot further infiltration to seal, seal the lubricants can be the starting point defoaming, sets the seal from the bubble bacteria often cause pollution.

1.3 How to choose fermentation Defoamer
Defoamer choose to comply with the following:
1, in the sparkling liquid in the insoluble or insoluble
As the bubble burst, defoamers should be concentrated in the bubble membrane, and concentrate. The breaking of the bubble, should be concentrated in an instant, the focus for the suppression foam should always keep in this state. So defoamer in the foaming solution is a saturation point, only insoluble insoluble or only easy to reach a saturation point. Insoluble or insoluble, it easier to gather in gas-liquid interface, easy to concentrate only in the bubble membrane, can play a role in low concentration. Defoamer for the water system, the active component elements, the weak shall be strong hydrophobic hydrophilic, HLB value in the 1.53 range, the role of only the best.
2, bubbling below the surface tension of
Defoamer only small force between molecules, bubbling below the surface tension of liquid, defoamers particles can immerse in water membrane and expansion. It is worth noting that the surface tension of liquid foaming solution is not the surface tension, but help the surface tension of water solution.
3, with the sparkling liquid to a certain degree of affinity
As anti-foaming process is actually the collapse of the bubble and the bubble generated at the speed of competition, so defoamer in the sparkling liquid must be able to quickly dispersed, in order to rapidly bubbling liquid in the broader context of a role to play. For the proliferation of fast Defoamer, defoamers active ingredients with liquid foaming with a certain degree of affinity. Defoamer active ingredients of a pro-foaming and will dissolve; too infrequent and difficult to spread. Only appropriate affinities, the effect will be good.
4, and there is no liquid foaming chemical reaction
Defoamers and foaming of the reaction, on the one hand defoamer will lose, on the other hand may have harmful substances, the impact on the growth of microorganisms.
5, volatile small role in a long time

1.4 for the fermentation industry with the type of defoamers
1, natural oils and fats (that is, soybean oil, corn oil)
Benefits: source of easy, low price, simple to use;
Disadvantages: If poor storage and easy to eradicating corruption, increased acidity of the fermentation poisonous.
2, polyether Defoamer
Tingduo types, mainly as follows:
a.GP-Defoamer: glycerol as the starting agent, from propylene oxide, or ethylene oxide and propylene oxide addition to the mixture and made of polymer.
GP-Defoamer hydrophilic poor, in the foam on the solubility of the medium, to use in thin broth of. Its suppression foam capacity than the anti-foaming superior ability, suitable for medium to add to curb the fermentation process of a bubble.
b.GPE-Defoamer: the bubble enemy, the GP-poly propylene glycol Defoamer coupled with the end of a chain of ethylene oxide, a chain-of-the hydrophilic Polyoxyethylene oxygen propylene Gan Oil, also called. In accordance with the addition of ethylene oxide to 10%, 20%,…… 50% respectively as GPE10, GPE20,…… GPE50.
GPE-Defoamer hydrophilic better, in the foam medium-spreading, anti-foaming ability, but also greater solubility, defoaming activity to maintain a short time, with the thick broth of better-performing.
c.GPES-Defoamer: a new polyether defoamers, in the GPE-Defoamer-linked with hydrophobic head of stearic acid ester, it is at both ends of a hydrophobic chain, which are hydrophilic interval Chain block copolymer. This structure of the molecule sits flat easy-gathered in the gas-liquid interface, thus surfactant strong, anti-foaming high efficiency.
3, higher alcohol
Higher Alcohol is weak water-drainage of the linear elements, in the water system is the effective defoamer. The early 1970s in the former Soviet Union scholars anions and cations, non-ionic surfactants solution test, proposed the anti-foaming alcohol, with its sparkling in the solubility of the extent and spread of the relevant. C7 ~ C9 of alcohol is the most effective defoamer.
C12 ~ C22 with the higher alcohol into the preparation of appropriate size for the emulsifier 4 ~ 9 μ m, in 20 to 50 percent of the water emulsion, that is, the water system defoamers.
Some also into ester, such as benzene oil ester alcohol, acid ester lauryl alcohol in fermentation, such as penicillin in the role of anti-foaming, which can be as precursors.
4, silicon category
The most commonly used is Polydimethylsiloxane, also known as dimethyl silicone oil. It can lower the surface, the lower the surface tension of the water and the general low solubility in the oil and high activity. It linked the main keys to silica, a non-polar molecule. And not pro-polar solvent and water, and generally have very little affinity oil. It is volatile and low-chemical inert, stable and toxicity. Pure Polydimethylsiloxane, without a decentralized difficult as defoamers. It may be due to high water and the interface tension, spreading low-coefficient, not scattered in the foam medium. So will SiO2 aerosol silicone oil mix, posed by the complex, soon after the hydrophobic SiO2 aerosol mixing dimethyl silicone oil, as a certain temperature, some time, can be obtained.
5, polyether modified silicone
Hengxin Chemical Technology Co., Ltd. in Yantai in 2002, successfully developed a professional for the fermentation industry and put into production Defoamer, polyether with a combination of silicone defoamer both the merits of a drug-free sound, the bacteria Sound, add a little volume, is a cost-effective products.
1.5 fermentation of a monosodium glutamate factory in the experimental report
1, the experiment was
Defoamers in the adoption and domestic production of comparative experiment to verify my company's production fermentation Defoamer effect.
2, experimental steps and associated data
Arbitrary fermentation workshop for the two fermentation tanks, tanks for experiments to increase over the same period the remaining ordinary Defoamer cans cans as a contrast cans, cans the same period compared with defoamer. Usage of the amount as follows: volume of 130 cubic meters fermentation tank, expected at the end of 10 KG, half-way flow increases expected at the end of 40 KG, together 50 KG. The first-time 15-16 hour refueling, the average-tank acid production 10.5% -10.6%, the volume of 102-104 million cubic metres-tank. 30-hour cycle.

The first batch of cans # 10 cans plus THIX-298 fermentation defoamer 5 KG, half-way flow increases defoamer 25 KG, the first time for 17-plus hours (cycle) finally put cans acid production 10.9 percent, from 11.1 retest samples %, Tank-size 104 cubic meters, the last remaining defoamer for 7 KG, defoamers consider the presence of water vapor condensing to the actual surplus to defoamer 3 KG, shared this award Defoamer 5 +25-3 = 27 KG . 30-hour cycle.

The second batch of cans 8 # fermenter, and the first batch of the remaining defoamer (aquifers) 7 KG at the end as expected, the half-way flow increases defoamer 20 KG (this experiment to provide 50 KG), the first time began to flow fuel cycle 14.5 Hours, the final acid-acid production 10.9%, 10.8% from re-testing. - Tank volume of 100 cubic meters, as expected at the end of aquifers, fed less, fermentation missing the first 24 hours defoamers, added the general defoamer 20 KG. After fermentation the last remaining factory ordinary aquifer defoamer 23 KG, the moisture content of which 7 KG, defoamers general terms equivalent to 1 KG, THIX-298 Defoamer equivalent to the final fermentation added (20-16) / 2 = 2 KG, to The second calculation can take up THIX-298 defoamer Total: 3 +20 +2 = 25 KG, the second cycle of 29 hours cans.
3 experimental conclusions:
Through trial and actual production of small-batch experiments, draw the following conclusions: THIX-298 Defoamer fermentation than the regular amount of savings defoamer 48% (50-26) / 50% 100% = 48%. Diyou is to halve. Defoamer the cell without harm, can increase the acid production 0.3% -0.4%, the group recommended further bulk testing done in the workshop.
1.6THIX-298 effective medicine for fermentation Defoamer safety data report (MSDS)
Hello users, if necessary please contact us ,0535-6130055.
1.7 How to compare performance and cost-effective use of defoamers
Regular customers have asked me, like how to determine which two defoamer in the end good. In fact, from theory numerical point of view, really do not tell, the most direct way is to do experiments, as mentioned in the 1.5 issue with the general THIX-298 and the defoamer polyether by the Experimental In fact, this is the most Intuitive, and it is the most effective. Furthermore the two defoamer in different system, the results may be different, so is mainly to experiment.